비글견의 두개골 결손부에 이식한 동종골과 자가골의 치유 비교: 예비 동물 실험
Comparison of Healing of Allograft and Autogenous Bone Implanted in the Skull Defect of Beagle Dog: Preliminary Animal Study
이중곤, 김상윤, 윤필영, 김영균,
소속 상세정보
이중곤 ( Lee Jung-Gon ) - 분당서울대학교병원 치과 구강악안면외과
김상윤 ( Kim Sang-Yun ) - 분당서울대학교병원 치과 구강악안면외과
윤필영 ( Yun Pil-Young ) - 분당서울대학교병원 치과 구강악안면외과
김영균 ( Kim Young-Kyun ) - 분당서울대학교병원 치과 구강악안면외과
Abstract
Purpose: The purpose of this study was to evaluate the healing process after autogenous and allogenous bone grafts for calvarial bone defects in beagles.
Materials and Methods: Two defects were formed in the skulls of two beagles and then grafted with a freeze-dried bone allograft (Double-Oss) and an autogenous bone chip, respectively. The clinical, radiographic, and histomorphometric examination results of the specimens taken 4 and 8 weeks after bone grafting were analyzed.
Results: The clinical, radiographic, and histological assessments revealed that 4 and 8 weeks after transplant, the beagle that received an autogenous bone graft was more likely to have high new bone formation than the beagle that had an allogenous bone. Four weeks after the transplant, the proportions of new bone formation were 11.5% and 35.8% in the allogenous and autogenous bones, respectively. Eight weeks after the transplant, the proportion of new bone formation with the allogenous bone increased significantly to 41.4% but was still less than the 65.6% with the autogenous bone.
Conclusion: The amount of new bone formation was smaller and the formation rate was slower with allogenous bone graft than with autogenous bone graft.
키워드
Allogenous bone; Autogenous bone; Bone graft
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